Cancer Screening Recommendations and Clinical Management of Inherited Gastrointestinal Cancer Syndromes in Childhood.
Identifieur interne : 001058 ( Main/Exploration ); précédent : 001057; suivant : 001059Cancer Screening Recommendations and Clinical Management of Inherited Gastrointestinal Cancer Syndromes in Childhood.
Auteurs : Maria Isabel Achatz [États-Unis] ; Christopher C. Porter [Géorgie (pays)] ; Laurence Brugières [France] ; Harriet Druker [Canada] ; Thierry Frebourg [France] ; William D. Foulkes [Canada] ; Christian P. Kratz [Allemagne] ; Roland P. Kuiper [Pays-Bas] ; Jordan R. Hansford [Australie] ; Hector Salvador Hernandez [Espagne] ; Katherine L. Nathanson [États-Unis] ; Wendy K. Kohlmann [États-Unis] ; Leslie Doros [États-Unis] ; Kenan Onel [États-Unis] ; Kami Wolfe Schneider [États-Unis] ; Sarah R. Scollon [États-Unis] ; Uri Tabori [Canada] ; Gail E. Tomlinson [États-Unis] ; D Gareth R. Evans [Royaume-Uni] ; Sharon E. Plon [États-Unis]Source :
- Clinical cancer research : an official journal of the American Association for Cancer Research [ 1078-0432 ] ; 2017.
Abstract
Hereditary gastrointestinal cancer predisposition syndromes have been well characterized, but management strategies and surveillance remain a major challenge, especially in childhood. In October 2016, the American Association for Cancer Research organized the AACR Childhood Cancer Predisposition Workshop in which international experts in care of children with a hereditary risk of cancer met to define surveillance strategies and management of children with cancer predisposition syndromes. In this article, we review the current literature in polyposis syndromes that can be diagnosed in childhood and may be associated with an increased incidence of gastrointestinal neoplasms and other cancer types. These disorders include adenomatous polyposis syndromes (APC and MUTYH), juvenile polyposis coli (BMPR1A and SMAD4), Peutz-Jeghers Syndrome (STK11/LKB1), and PTEN hamartoma tumor syndrome (PHTS; PTEN), which can present with a more limited juvenile polyposis phenotype. Herein, the panel of experts provides recommendations for clinical diagnosis, approach to genetic testing, and focus on cancer surveillance recommendations when appropriate during the pediatric period. We also review current controversies on genetic evaluation of patients with hepatoblastoma and indications for surveillance for this tumor. Childhood cancer risks and surveillance associated with disorders involving the mismatch repair genes, including Lynch syndrome and constitutional mismatch repair deficiency (CMMRD), are discussed elsewhere in this series. Clin Cancer Res; 23(13); e107-e14. ©2017 AACRSee all articles in the online-only CCR Pediatric Oncology Series.
DOI: 10.1158/1078-0432.CCR-17-0790
PubMed: 28674119
Affiliations:
- Allemagne, Australie, Canada, Espagne, France, Géorgie (pays), Pays-Bas, Royaume-Uni, États-Unis
- Angleterre, Basse-Saxe, Catalogne, Colorado, District de Columbia, Grand Manchester, Haute-Normandie, Maryland, Ontario, Pennsylvanie, Québec, Région Normandie, Texas, Utah, Utrecht (province), Victoria (État), État de New York
- Barcelone, Hanovre, Manchester, Melbourne, Montréal, Rouen, Toronto, Utrecht
- Université McGill, Université de Manchester, Université de Melbourne, Université de Toronto
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Scollon</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, Division of Hematology/Oncology, Baylor College of Medicine, Houston, Texas.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Pediatrics, Division of Hematology/Oncology, Baylor College of Medicine, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Tabori, Uri" sort="Tabori, Uri" uniqKey="Tabori U" first="Uri" last="Tabori">Uri Tabori</name><affiliation wicri:level="4"><nlm:affiliation>Division of Hematology/Oncology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology/Oncology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Tomlinson, Gail E" sort="Tomlinson, Gail E" uniqKey="Tomlinson G" first="Gail E" last="Tomlinson">Gail E. Tomlinson</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatric Hematology-Oncology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Pediatric Hematology-Oncology, The University of Texas Health Science Center at San Antonio, San Antonio</wicri:cityArea></affiliation></author><author><name sortKey="Evans, D Gareth R" sort="Evans, D Gareth R" uniqKey="Evans D" first="D Gareth R" last="Evans">D Gareth R. Evans</name><affiliation wicri:level="4"><nlm:affiliation>Department of Genomic Medicine, University of Manchester, St. Mary's Hospital, Manchester, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Genomic Medicine, University of Manchester, St. Mary's Hospital, Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region><settlement type="city">Manchester</settlement></placeName><orgName type="university">Université de Manchester</orgName></affiliation></author><author><name sortKey="Plon, Sharon E" sort="Plon, Sharon E" uniqKey="Plon S" first="Sharon E" last="Plon">Sharon E. 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Porter</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia.</nlm:affiliation><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Department of Pediatrics, Emory University School of Medicine, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Brugieres, Laurence" sort="Brugieres, Laurence" uniqKey="Brugieres L" first="Laurence" last="Brugières">Laurence Brugières</name><affiliation wicri:level="1"><nlm:affiliation>Child and Adolescent Cancer Department, Gustave Roussy Cancer Campus, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Child and Adolescent Cancer Department, Gustave Roussy Cancer Campus, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Druker, Harriet" sort="Druker, Harriet" uniqKey="Druker H" first="Harriet" last="Druker">Harriet Druker</name><affiliation wicri:level="4"><nlm:affiliation>Division of Hematology/Oncology, Department of Genetic Counselling, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology/Oncology, Department of Genetic Counselling, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Frebourg, Thierry" sort="Frebourg, Thierry" uniqKey="Frebourg T" first="Thierry" last="Frebourg">Thierry Frebourg</name><affiliation wicri:level="3"><nlm:affiliation>Department of Genetics, Rouen University Hospital, Rouen, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Genetics, Rouen University Hospital, Rouen</wicri:regionArea><placeName><region type="region">Région Normandie</region><region type="old region">Haute-Normandie</region><settlement type="city">Rouen</settlement></placeName></affiliation></author><author><name sortKey="Foulkes, William D" sort="Foulkes, William D" uniqKey="Foulkes W" first="William D" last="Foulkes">William D. Foulkes</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Oncology and Human Genetics, McGill University, Montreal, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, Oncology and Human Genetics, McGill University, Montreal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region><settlement type="city">Montréal</settlement></placeName><orgName type="university">Université McGill</orgName></affiliation></author><author><name sortKey="Kratz, Christian P" sort="Kratz, Christian P" uniqKey="Kratz C" first="Christian P" last="Kratz">Christian P. Kratz</name><affiliation wicri:level="3"><nlm:affiliation>Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Pediatric Hematology and Oncology, Hannover Medical School, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Kuiper, Roland P" sort="Kuiper, Roland P" uniqKey="Kuiper R" first="Roland P" last="Kuiper">Roland P. Kuiper</name><affiliation wicri:level="3"><nlm:affiliation>Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Princess Máxima Center for Pediatric Oncology, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Hansford, Jordan R" sort="Hansford, Jordan R" uniqKey="Hansford J" first="Jordan R" last="Hansford">Jordan R. Hansford</name><affiliation wicri:level="4"><nlm:affiliation>Children's Cancer Centre, Royal Children's Hospital; Murdoch Children's Research Institute; University of Melbourne, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Children's Cancer Centre, Royal Children's Hospital; Murdoch Children's Research Institute; University of Melbourne, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region><settlement type="city">Melbourne</settlement></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Hernandez, Hector Salvador" sort="Hernandez, Hector Salvador" uniqKey="Hernandez H" first="Hector Salvador" last="Hernandez">Hector Salvador Hernandez</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pediatric OncoHematology, Hospital Sant Joan de Déu, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Pediatric OncoHematology, Hospital Sant Joan de Déu, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L" last="Nathanson">Katherine L. Nathanson</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, the University of Pennsylvania, Philadelphia, Pennsylvania.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Medicine, the University of Pennsylvania, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Kohlmann, Wendy K" sort="Kohlmann, Wendy K" uniqKey="Kohlmann W" first="Wendy K" last="Kohlmann">Wendy K. Kohlmann</name><affiliation wicri:level="2"><nlm:affiliation>Population Health Sciences Department, Huntsman Cancer Institute, Salt Lake City, Utah.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Utah</region></placeName><wicri:cityArea>Population Health Sciences Department, Huntsman Cancer Institute, Salt Lake City</wicri:cityArea></affiliation></author><author><name sortKey="Doros, Leslie" sort="Doros, Leslie" uniqKey="Doros L" first="Leslie" last="Doros">Leslie Doros</name><affiliation wicri:level="2"><nlm:affiliation>Cancer Genetics Clinic, Children's National Medical Center, Washington, DC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">District de Columbia</region></placeName><wicri:cityArea>Cancer Genetics Clinic, Children's National Medical Center, Washington</wicri:cityArea></affiliation></author><author><name sortKey="Onel, Kenan" sort="Onel, Kenan" uniqKey="Onel K" first="Kenan" last="Onel">Kenan Onel</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, Hofstra-Northwell School of Medicine and Cohen Children's Medical Center, Manhasset, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Pediatrics, Hofstra-Northwell School of Medicine and Cohen Children's Medical Center, Manhasset</wicri:cityArea></affiliation></author><author><name sortKey="Schneider, Kami Wolfe" sort="Schneider, Kami Wolfe" uniqKey="Schneider K" first="Kami Wolfe" last="Schneider">Kami Wolfe Schneider</name><affiliation wicri:level="2"><nlm:affiliation>Division of Hematology, Oncology, Bone Marrow Transplant, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora, Colorado.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Colorado</region></placeName><wicri:cityArea>Division of Hematology, Oncology, Bone Marrow Transplant, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora</wicri:cityArea></affiliation></author><author><name sortKey="Scollon, Sarah R" sort="Scollon, Sarah R" uniqKey="Scollon S" first="Sarah R" last="Scollon">Sarah R. Scollon</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, Division of Hematology/Oncology, Baylor College of Medicine, Houston, Texas.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Pediatrics, Division of Hematology/Oncology, Baylor College of Medicine, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Tabori, Uri" sort="Tabori, Uri" uniqKey="Tabori U" first="Uri" last="Tabori">Uri Tabori</name><affiliation wicri:level="4"><nlm:affiliation>Division of Hematology/Oncology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Hematology/Oncology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Tomlinson, Gail E" sort="Tomlinson, Gail E" uniqKey="Tomlinson G" first="Gail E" last="Tomlinson">Gail E. Tomlinson</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatric Hematology-Oncology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Pediatric Hematology-Oncology, The University of Texas Health Science Center at San Antonio, San Antonio</wicri:cityArea></affiliation></author><author><name sortKey="Evans, D Gareth R" sort="Evans, D Gareth R" uniqKey="Evans D" first="D Gareth R" last="Evans">D Gareth R. Evans</name><affiliation wicri:level="4"><nlm:affiliation>Department of Genomic Medicine, University of Manchester, St. Mary's Hospital, Manchester, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Genomic Medicine, University of Manchester, St. Mary's Hospital, Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region><settlement type="city">Manchester</settlement></placeName><orgName type="university">Université de Manchester</orgName></affiliation></author><author><name sortKey="Plon, Sharon E" sort="Plon, Sharon E" uniqKey="Plon S" first="Sharon E" last="Plon">Sharon E. Plon</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, Division of Hematology/Oncology, Baylor College of Medicine, Houston, Texas.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Pediatrics, Division of Hematology/Oncology, Baylor College of Medicine, Houston</wicri:cityArea></affiliation></author></analytic><series><title level="j">Clinical cancer research : an official journal of the American Association for Cancer Research</title><idno type="ISSN">1078-0432</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Hereditary gastrointestinal cancer predisposition syndromes have been well characterized, but management strategies and surveillance remain a major challenge, especially in childhood. In October 2016, the American Association for Cancer Research organized the AACR Childhood Cancer Predisposition Workshop in which international experts in care of children with a hereditary risk of cancer met to define surveillance strategies and management of children with cancer predisposition syndromes. In this article, we review the current literature in polyposis syndromes that can be diagnosed in childhood and may be associated with an increased incidence of gastrointestinal neoplasms and other cancer types. These disorders include adenomatous polyposis syndromes (APC and MUTYH), juvenile polyposis coli (BMPR1A and SMAD4), Peutz-Jeghers Syndrome (STK11/LKB1), and PTEN hamartoma tumor syndrome (PHTS; PTEN), which can present with a more limited juvenile polyposis phenotype. Herein, the panel of experts provides recommendations for clinical diagnosis, approach to genetic testing, and focus on cancer surveillance recommendations when appropriate during the pediatric period. We also review current controversies on genetic evaluation of patients with hepatoblastoma and indications for surveillance for this tumor. Childhood cancer risks and surveillance associated with disorders involving the mismatch repair genes, including Lynch syndrome and constitutional mismatch repair deficiency (CMMRD), are discussed elsewhere in this series. Clin Cancer Res; 23(13); e107-e14. ©2017 AACRSee all articles in the online-only CCR Pediatric Oncology Series.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Canada</li><li>Espagne</li><li>France</li><li>Géorgie (pays)</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Basse-Saxe</li><li>Catalogne</li><li>Colorado</li><li>District de Columbia</li><li>Grand Manchester</li><li>Haute-Normandie</li><li>Maryland</li><li>Ontario</li><li>Pennsylvanie</li><li>Québec</li><li>Région Normandie</li><li>Texas</li><li>Utah</li><li>Utrecht (province)</li><li>Victoria (État)</li><li>État de New York</li></region><settlement><li>Barcelone</li><li>Hanovre</li><li>Manchester</li><li>Melbourne</li><li>Montréal</li><li>Rouen</li><li>Toronto</li><li>Utrecht</li></settlement><orgName><li>Université McGill</li><li>Université de Manchester</li><li>Université de Melbourne</li><li>Université de Toronto</li></orgName></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Achatz, Maria Isabel" sort="Achatz, Maria Isabel" uniqKey="Achatz M" first="Maria Isabel" last="Achatz">Maria Isabel Achatz</name></region><name sortKey="Doros, Leslie" sort="Doros, Leslie" uniqKey="Doros L" first="Leslie" last="Doros">Leslie Doros</name><name sortKey="Kohlmann, Wendy K" sort="Kohlmann, Wendy K" uniqKey="Kohlmann W" first="Wendy K" last="Kohlmann">Wendy K. Kohlmann</name><name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L" last="Nathanson">Katherine L. Nathanson</name><name sortKey="Onel, Kenan" sort="Onel, Kenan" uniqKey="Onel K" first="Kenan" last="Onel">Kenan Onel</name><name sortKey="Plon, Sharon E" sort="Plon, Sharon E" uniqKey="Plon S" first="Sharon E" last="Plon">Sharon E. Plon</name><name sortKey="Schneider, Kami Wolfe" sort="Schneider, Kami Wolfe" uniqKey="Schneider K" first="Kami Wolfe" last="Schneider">Kami Wolfe Schneider</name><name sortKey="Scollon, Sarah R" sort="Scollon, Sarah R" uniqKey="Scollon S" first="Sarah R" last="Scollon">Sarah R. Scollon</name><name sortKey="Tomlinson, Gail E" sort="Tomlinson, Gail E" uniqKey="Tomlinson G" first="Gail E" last="Tomlinson">Gail E. Tomlinson</name></country><country name="Géorgie (pays)"><noRegion><name sortKey="Porter, Christopher C" sort="Porter, Christopher C" uniqKey="Porter C" first="Christopher C" last="Porter">Christopher C. Porter</name></noRegion></country><country name="France"><noRegion><name sortKey="Brugieres, Laurence" sort="Brugieres, Laurence" uniqKey="Brugieres L" first="Laurence" last="Brugières">Laurence Brugières</name></noRegion><name sortKey="Frebourg, Thierry" sort="Frebourg, Thierry" uniqKey="Frebourg T" first="Thierry" last="Frebourg">Thierry Frebourg</name></country><country name="Canada"><region name="Ontario"><name sortKey="Druker, Harriet" sort="Druker, Harriet" uniqKey="Druker H" first="Harriet" last="Druker">Harriet Druker</name></region><name sortKey="Foulkes, William D" sort="Foulkes, William D" uniqKey="Foulkes W" first="William D" last="Foulkes">William D. Foulkes</name><name sortKey="Tabori, Uri" sort="Tabori, Uri" uniqKey="Tabori U" first="Uri" last="Tabori">Uri Tabori</name></country><country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Kratz, Christian P" sort="Kratz, Christian P" uniqKey="Kratz C" first="Christian P" last="Kratz">Christian P. Kratz</name></region></country><country name="Pays-Bas"><region name="Utrecht (province)"><name sortKey="Kuiper, Roland P" sort="Kuiper, Roland P" uniqKey="Kuiper R" first="Roland P" last="Kuiper">Roland P. Kuiper</name></region></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Hansford, Jordan R" sort="Hansford, Jordan R" uniqKey="Hansford J" first="Jordan R" last="Hansford">Jordan R. Hansford</name></region></country><country name="Espagne"><region name="Catalogne"><name sortKey="Hernandez, Hector Salvador" sort="Hernandez, Hector Salvador" uniqKey="Hernandez H" first="Hector Salvador" last="Hernandez">Hector Salvador Hernandez</name></region></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Evans, D Gareth R" sort="Evans, D Gareth R" uniqKey="Evans D" first="D Gareth R" last="Evans">D Gareth R. Evans</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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